
Which metabolic pathway converts one glucose molecule into two molecules of pyruvate?
Glycogenesis
Glycolysis
Glycolysis
Glycogenolysis
Where does glycolysis take place in the cell?
Mitochondrial matrix
Inner mitochondrial membrane
Cytosol
Nucleus
Which enzyme catalyzes the first step of glycolysis, converting glucose into glucose-6-phosphate?
Hexokinase
Aldolase
Enolase
Pyruvate kinase
Which enzyme converts fructose-6-phosphate into fructose-1,6-bisphosphate?
Phosphoglucose isomerase
Phosphoglycerate kinase
Triose phosphate isomerase
Phosphofructokinase-1
Which enzyme splits fructose-1,6-bisphosphate into two three-carbon molecules?
Hexokinase
Aldolase
Enolase
Lactate dehydrogenase
Which enzyme converts 2-phosphoglycerate into phosphoenolpyruvate (PEP)?
Pyruvate kinase
Phosphoglycerate mutase
Enolase
Phosphoglycerate kinase
Which enzyme produces NADH during the conversion of glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate?
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglucose isomerase
Aldolase
Hexokinase
Which type of phosphorylation occurs when PEP transfers its phosphate group to ADP to produce ATP?
Oxidative phosphorylation
Photophosphorylation
Phosphorylation by NADH
Substrate-level phosphorylation
What is the net yield of glycolysis per glucose molecule?
4 ATP, 2 NADH, and 2 pyruvate
2 ATP, 2 NADH, and 2 pyruvate
2 ATP, 4 NADH, and 1 pyruvate
6 ATP, 2 NADH, and 2 pyruvate
High concentrations of which substances inhibit phosphofructokinase-1?
ADP and AMP
Glucose and pyruvate
ATP and citrate
Lactate and glucose-6-phosphate
Why are NADH shuttle mechanisms needed during aerobic glycolysis?
NADH cannot be produced in the cytosol.
The mitochondrial membrane is impermeable to NADH itself.
ATP cannot enter mitochondria.
Pyruvate cannot enter mitochondria.
Which shuttle is associated with heart and liver cells and yields approximately 2.5 ATP per NADH in the slides?
Glycerol-3-phosphate shuttle
Cori cycle
Pentose phosphate pathway
Malate-aspartate shuttle
How much ATP is attributed to each cytosolic NADH transferred through the glycerol-3-phosphate shuttle?
1.5 ATP
2 ATP
2.5 ATP
3 ATP
According to the slides, what is the total ATP yield from complete aerobic oxidation of one glucose molecule using the malate-aspartate shuttle?
24 ATP
28 ATP
32 ATP
36 ATP
Which process synthesizes glucose from noncarbohydrate sources such as lactate, glycerol, and certain amino acids?
Glycolysis
Glycogenesis
Glycogenolysis
Gluconeogenesis
Which organ is the primary site of gluconeogenesis according to the slides?
Heart
Liver
Brain
Skeletal muscle
During strenuous exercise, lactate travels from the muscles to the liver, where it is converted into glucose that returns to the muscles. What is this process called?
Cori cycle
TCA cycle
Urea cycle
Electron transport chain
What is the process of forming glycogen from glucose for storage in the liver and muscles?
Glycogenolysis
Gluconeogenesis
Glycogenesis
Glycolysis
Which process breaks down stored glycogen to help increase blood glucose levels?
Glycogenesis
Glycogenolysis
Glycolysis
Lipogenesis
Which enzyme is a key enzyme in glycogen synthesis?
Glycogen phosphorylase
Lactate dehydrogenase
Glucose-6-phosphate dehydrogenase
Glycogen synthase
Which enzyme is primarily responsible for glycogen breakdown?
Glycogen phosphorylase
Glycogen synthase
Hexokinase
Phosphofructokinase-1
Which hormone stimulates glycogenesis during the fed state?
Glucagon
Epinephrine
Insulin
Adrenaline
Which metabolic pathway produces NADPH and ribose-5-phosphate?
Glycolysis
Pentose phosphate pathway
Glycogenolysis
Cori cycle
What is another name for the pentose phosphate pathway?
Krebs cycle
Embden-Meyerhof-Parnas pathway
Electron transport chain
Hexose monophosphate shunt
Where does the pentose phosphate pathway occur?
Cytosol
Mitochondrial matrix
Inner mitochondrial membrane
Nucleus
Which product is formed during the oxidative phase of the pentose phosphate pathway?
Pyruvate
Acetyl-CoA
Ribulose-5-phosphate
Glycogen
Which products are generated during the oxidative phase of the pentose phosphate pathway?
ATP and pyruvate
NADPH and ribulose-5-phosphate
Glycogen and glucose
Acetyl-CoA and NADH
Which hormone is released by pancreatic beta cells when blood glucose levels are high?
Glucagon
Epinephrine
Adrenaline
Insulin
Which hormone is released by pancreatic alpha cells when blood glucose levels are low?
Glucagon
Insulin
Thyroxine
Melatonin
Which hormone stimulates glycogenolysis during an acute stress response and is also known as adrenaline?
Insulin
Glucagon
Epinephrine
Thyroxine
Which statement best describes diabetes mellitus?
Excessive glycogen storage is the only cause.
The body produces insufficient insulin or cells do not respond properly to insulin.
The body cannot produce NADPH.
The body cannot synthesize ribose-5-phosphate.
Which enzyme deficiency is associated with essential fructosuria?
Aldolase B
Galactokinase
Glucose-6-phosphate dehydrogenase
Fructokinase
A patient develops severe hypoglycemia, vomiting, and liver dysfunction after consuming fructose. Which enzyme deficiency is most consistent with hereditary fructose intolerance?
Aldolase B deficiency
Fructokinase deficiency
Hexokinase deficiency
Glycogen synthase deficiency
Which enzyme deficiency is associated with classic galactosemia (Type I) in the slides?
Fructokinase
Galactokinase
Galactose-1-phosphate uridylyltransferase (GALT)
Glucose-6-phosphate dehydrogenase
A patient develops fatigue, jaundice, dark tea-colored urine, and hemolytic anemia following oxidative stress. Which enzyme deficiency is most consistent with these findings?
Aldolase B deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Fructokinase deficiency
Glycogen synthase deficiency