Peripheral Neuropathy
Question 1
Which type of peripheral neuropathy is characterized by primary axonal injury starting distally?
Demyelinating Neuropathy
Axonal Neuropathy
Neuronopathy
Ischemic Neuropathy
Question 2
Which distribution is classically seen in axonal neuropathy?
Facial Distribution
Proximal Limb Weakness
Stocking-Glove Distribution
Dermatomal Distribution
Question 3
Demyelinating neuropathy primarily involves damage to which structure?
Axon Terminal
Neuromuscular Junction
Myelin Sheath / Schwann Cell
Dorsal Root Ganglion
Question 4
Which clinical finding is most associated with demyelinating neuropathy?
Reduced nerve conduction velocity
Increase nerve conduction amplitude
Early loss of pain sensation early
Normal CSF protein
Question 5
Which condition is an example of a somatic motor neuronopathy?
Guillain-Barre Syndrome
Amyotrophic Lateral Sclerosis (ALS)
Diabetic Neuropathy
Carpal Tunnel Syndrome
Question 6
Ischaemic neuropathy is most commonly caused by
Chronic Hyperglycemia
Immune Attack on Myelin
Inflammation and occlusion of vasa nervorum
Vitamin B12 deficiency
Question 7
Which TWO features are typical of ischaemic neuropathy?
Gradual Onset
Acute Onset
Symmetrical Involvement
Painful & Asymmetrical Deficits
Question 8
Which metabolic mechanism contributes to diabetic neuropathy?
Reduced acetylcholine synthesis
Polyol (sorbitol) pathway activation
Excess dopamine production
Increased myelin thickness
Question 9
Which symptom is considered an autonomic feature of peripheral neuropathy?
Muscle Wasting
Orthostatic hypotension
Loss of vibration sense
Reduced ankle reflex
Question 10
Which investigation is most useful for detecting vitamin B12 or folate deficiency?
Thyroid function test
Renal Function Test
Liver Function Test
Full blood count showing high MCV