PHARMACOLOGY B topics
pharmacology B topic game! will include the ff topics: Antidiabetic agents, Thyroid/Antithyroids and Agents acting on the Bone, Adrenocorticosteroids and Drugs Acting on the Reproductive System, Anti-TB/Anti-fungals, and Antiviral agents.
Question 1
Antidiabetic agents
Oral anti-diabetic agent that can enhance insulin secretion in glucose dependent manner
Canagliflozin
Pioglitazone
Linagliptin
Miglitol
Question 2
Antidiabetic agents
The following is TRUE of insulin glargine
Midnight snack may prevent hypoglycemic attack in the middle of the night
Maybe given 2x a week because of its long action
soluble in an basic solution but precipitates in acidic body pH after SC
Has a pH of 4
Question 3
Antidiabetic agents
Which of the following adverse effects is/are likely to be experienced by a patient given metformin?
Hypoglycemia
Hematuria
Diarrhea
A and C only
Question 4
Antidiabetic agents
Which of the following is responsible for the therapeutic effects of GLYBURIDE?
Activation of PPAR-a receptors in the liver
Inhibition of ATP sensitive K channel
Activation of Tyrosine kinase receptors
Inhibition of GLUT in the pancreas
Question 5
Thyroid/Antithyroids and Agents acting on the Bone
Which of the following statements is associated with denosumab?
Administered orally best taken with food
inhibits osteoclasts formation and activity
Binds and stimulates RANK ligand activity
Activates calcium sensing receptors
Question 6
Thyroid/Antithyroids and Agents acting on the Bone
A 55-year old woman with bone pain has a DEXA result of -2.5. Her renal and liver function tests are all normal. If she prefers an oral agent, which will be MOST preferred as initial treatment?
denosumab
risedronate
calcitonin
zolendronic acid
Question 7
Thyroid/Antithyroids and Agents acting on the Bone
A 53-year old female maintained on levothyroxine, has also been taking calcium supplements with it. Which of the following is expected to occur with levothyroxine?
Half-life will be prolonged
Pharmacologic action increased
Absorption will be reduced
Metabolism accelerated
Question 8
Thyroid/Antithyroids and Agents acting on the Bone
A 54-year old male is on calcium carbonate and is often on high sodium and protein diet. Which of the following effects is expected to occur with calcium carbonate?
depletion of calcium stores
enhanced metabolism
increased urinary excretion
reduced absorption
Question 9
Adrenocorticosteroids and Drugs Acting on the Reproductive System
prednisone for 3 months developed edema and slight elevation in blood pressure. Which of the following actions/effects is the MOST likely cause?
immunosuppressant activity
increased blood glucose level
mineralocorticoid activity
high protein binding
Question 10
Adrenocorticosteroids and Drugs Acting on the Reproductive System
Which of the following is the mechanisms of action of eplerenone?
stabilize hsp90 and steroid receptor complex
. inhibit cholesterol side chain cleavage
competition with aldosterone receptor
inhibit 17-alpha hydroxylase
Question 11
Adrenocorticosteroids and Drugs Acting on the Reproductive System
which of the following is expected to increase with OCPs if the patient will be given rifampicin for the treatment of pulmonary tuberculosis?
excretion
contraceptive activity
metabolism
absorption
Question 12
Adrenocorticosteroids and Drugs Acting on the Reproductive System
If a 30-year old nulligravid with polycystic ovarian syndrome wants to have regular menses but is NOT desirous of pregnancy, which agent will be BEST to treat her condition?
combined oral contraceptive pills
goserilin
letrozole
ethinyl estradiol
Question 13
Anti-TB/Antifungals
Visual disturbance: You are considering retrobulbar neuritis, which of the following agents could have caused this?
Rifampicin
Pyrazinamide
Isoniazid
Ethambutol
Question 14
Anti-TB/Antifungals
what is the MOA of ethambutol?
inhibits mycobacterial arabinosyl transferases, encoded by the embCAB operon
binds to the B subunit of bacterial DNA-dependent RNA polymerase, thereby inhibiting RNA synthesis
Inhibit mycolic acid synthesis
NOTA
Question 15
Anti-TB/Antifungals
The most widely used anti-fungal drug; widest therapeutic index.
Fluconazole
Butenafine
Nystatin
amphotericin B
Question 16
Anti-TB/Antifungals
Which of the following antifungals has the greatest propensity to inhibit human cytochrome P450 enzyme?
Itraconazole
Ketoconazole
Amphotericin B
Flucytosine
Question 17
Antiviral agents
Which of the following enzymes is inhibited by entecavir?
Thymidine kinase
Phosphotransferase
RNA polymerase
DNA polymerase
Question 18
Antiviral agents
Which drug protects Nirmatrelvir from being broken down so that Nirmatrelvir will have longer duration of action?
Remdesivir
Molnupiravir
Ritonavir
Adefovir
Question 19
Antiviral agents
A 25-year-old woman consulted due to genital burning pain for the past 2 days which became worse on urination. Physical examination revealed multiple blisters and ulcerative lesions in the vaginal area. What agent will be the drug of choice for this case?
Foscarnet
Oseltamivir
Ribavirin
Acyclovir
Question 20
Antiviral agents
which of the following is FALSE for the use of Valacyclovir
Treatment of first and recurrent genital herpes
Suppression of frequent recurring genital herpes
long term treatment (6 months-1 year) of orolabial herpes
Treatment of herpes zoster
Question 21
BONUS! Sino pinaka maganda, mabait, at best precept/professor sa pharma
Doc Ravelo
Doc Ravelo
Doc Ravelo
Doc Ravelo